Neighborhood matters: Response to EZH2 methyltransferase inhibitors
نویسندگان
چکیده
Neighborhood matters: Response to EZH2 methyltransferase inhibitors Comment on: Amatangelo MD, et al. Cell Cycle 2013; 12:2113–9; PMID:23759589; http://dx.doi.org/10.4161/cc.25163 Kshipra M Gharpure and Anil K Sood*; Department of Gynecologic Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Center for RNA Interference and Non-Coding RNAs; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Cancer Biology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; *Email: [email protected]; http://dx.doi.org/10.4161/cc.25775
منابع مشابه
Sizing up circulating tumor cells for personalized therapy
Neighborhood matters: Response to EZH2 methyltransferase inhibitors Comment on: Amatangelo MD, et al. Cell Cycle 2013; 12:2113–9; PMID:23759589; http://dx.doi.org/10.4161/cc.25163 Kshipra M Gharpure and Anil K Sood*; Department of Gynecologic Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Center for RNA Interference and Non-Coding RNAs; The University of Texas MD ...
متن کامل“Naked” FACT is unstable
Neighborhood matters: Response to EZH2 methyltransferase inhibitors Comment on: Amatangelo MD, et al. Cell Cycle 2013; 12:2113–9; PMID:23759589; http://dx.doi.org/10.4161/cc.25163 Kshipra M Gharpure and Anil K Sood*; Department of Gynecologic Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Center for RNA Interference and Non-Coding RNAs; The University of Texas MD ...
متن کاملPoly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage
The enzyme Poly(ADP-ribose) polymerase 1 (PARP1) plays a very important role in the DNA damage response, but its role in numerous aspects is not fully understood. We recently showed that in the absence of DNA damage, PARP1 regulates the expression of the chromatin-modifying enzyme EZH2. Work from other groups has shown that EZH2 participates in the DNA damage response. These combined data sugge...
متن کاملA covalently bound inhibitor triggers EZH2 degradation through CHIP‐mediated ubiquitination
Enhancer of zeste homolog 2 (EZH2) has been characterized as a critical oncogene and a promising drug target in human malignant tumors. The current EZH2 inhibitors strongly suppress the enhanced enzymatic function of mutant EZH2 in some lymphomas. However, the recent identification of a PRC2- and methyltransferase-independent role of EZH2 indicates that a complete suppression of all oncogenic f...
متن کاملEZH2 as a therapeutic target in solid tumors
Epigenetic alterations are an important hallmark of cancer, and the enzymes that modify histone tails have emerged as attractive drug targets. The histone methyltransferase EZH2 is the catalytic subunit of PRC2, a highly conserved protein complex that regulates gene expression by methylating lysine 27 on histone H3. EZH2 is frequently overexpressed in cancer, and oncogenic gain-of-function muta...
متن کامل